Anti-obesity effects of Rapha diet¢ç preparation in
mice fed a high-fat diet
Jihyun Kim, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Paul Bang, Dongsun Park, Yun-Bae Kim
The anti-obesity activities of Rapha diet¢ç preparation containing silkworm pupa peptide, Garcinia cambogia,
white bean extract, mango extract, raspberry extract, cocoa extract, and green tea extract were
investigated in mice with dietary obesity. Male C57BL/6 mice were fed a high-fat diet (HFD) containing
3% Rapha diet¢ç preparation for 8 weeks, and blood and tissue parameters of obesity were analyzed. The
HFD markedly enhanced body weight gain by increasing the weights of epididymal, perirenal, and
mesenteric adipose tissues. The increased body weight gain induced by HFD was significantly reduced by
feeding Rapha diet¢ç preparation, in which decreases in the weight of abdominal adipose tissue and the
size of abdominal adipocytes were confirmed by microscopic examination. Long-term feeding of HFD
increased blood triglycerides and cholesterol levels, leading to hepatic lipid accumulation. However,
Rapha diet¢ç preparation not only reversed the blood lipid levels, but also attenuated hepatic steatosis.
The results indicate that Rapha diet¢ç preparation could improve HFD-induced obesity by reducing both
lipid accumulation and the size of adipocytes.